The OrthoKEY Outpatient test provides diagnostic insights for infections of the joints, including septic arthritis, osteomyelitis, prosthetic joint infections (PJI), and other joint infections. It is particularly valuable for chronic, recurrent, and culture-negative infections, as well as cases where patients have received prior antibiotic therapy, which can suppress bacterial growth in conventional cultures. Additionally, the test supports pre-surgical evaluation for prosthetic joint replacement, helping identify potential bacterial colonization that may increase the risk of post-operative infections 

Rapid sequencing using NGS technology powered by advanced bioinformatics enables broad microbial identification, detecting over 50,000 bacterial and fungal targets in a single sample. qPCR enables rapid detection of bacterial load and targeted pathogen identification, improving diagnostic sensitivity. The test also screens for 17 antibiotic resistance genes, aiding in antimicrobial selection. 

Validated for synovial fluid aspiration and swab samples, the test includes a sample collection kit and reports results within 3–5 days, providing timely and accurate pathogen detection, supporting informed clinical decision-making in outpatient settings.